TCRC50 Dual-Column Recirculating Chromatography System
Category:
- Product Description
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Application scenarios:
The dual-column preparative liquid chromatography system is suitable for the separation and purification of complex samples, difficult-to-separate components, and high-throughput applications, and can be used for the preparation of the following compounds.
1) Chiral Sample Resolution and Preparation
2) Separation and purification of peptides
3) Purification of small-molecule compounds
Working principle:
By employing two 2/4-way valves, the pipeline configuration is shorter and the connection between the two columns is more flexible compared to the conventional use of a single 2/6-way or 2/8-way valve; the valves can be connected in series or operated independently.
*Dual-detector, dual-wavelength detection ensures continuous monitoring of the separation process.
*Full-process automatic control
Technological Advantages
1. Compared with conventional preparative chromatography, under the same yield conditions, the sample load can be increased by several-fold to more than dozens of times, and solvent consumption is reduced by over 50%.
2. Suitable for impurity separation and purification, preparative purification of peptide samples, chiral resolution, and purification of natural products, among other applications.
3. Significantly reduced separation time: Thanks to the synergistic operation of dual columns and a cyclic separation mechanism, sample separation times are markedly shorter than those achieved with conventional single-column systems.
4. Significantly improved separation yield: The separation yield of dual-column preparative chromatography is several to dozens of times higher than that of single-column chromatography.
5. Improved control of peak broadening: Without the need for high-pressure pump recirculation, components are separated solely within the chromatographic column, effectively minimizing peak broadening and delivering superior separation performance.
6. Flexible system configuration: The dual-column liquid chromatography system allows for flexible connection or disconnection of upstream and downstream columns, with short extra-column tubing and minimal system dead volume.
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